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BRENNAN, J., filed an opinion concurring in part and dissenting in part, post, p.
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Des études ont montré que chez les patients atteints d'athérosclérose établie, d'insuffisance cardiaque ou de diabète avec atteinte des organes cibles, un double blocage du système rénine angiotensine aldostérone est associé à une fréquence plus élevée d'hypotension, de syncope, d'hyperkaliémie et de modifications de la fonction rénale (y compris l'insuffisance rénale aiguë), comparée à l'utilisation d'un seul inhibiteur du système rénine angiotensine aldostérone. Drug is released from the dosage form by a process of diffusion or erosion through the gel matrix that is essentially independent of pH.

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